Similarly, circ_0008035 has been shown to function as a promoter in GC by enhancing cancer cell growth and metastasis via miR-1256/CFACAM6 and miR-375/YBX1 axes.14,27 Moreover, Gao et al. reported that dexmedetomidine elevated circ_0008035 expression to contribute to GC cell ferroptosis through the miR-302a/E2F7 cascade.28 These findings suggest that the circ_0008035/miR-429/SMAD2, circ_0008035/miR-1256/CFACAM6, circ_0008035/miR-375/YBX1, and circ_0008035/miR-302a/E2F7 axes may form a regulatory network, which is implicated in GC development. The gene discussed is SMAD2; the disease is cancer.