POLR2J4 and hepatocellular carcinoma: For example, the downregulation of miR-214-3p in retinoblastoma mediates tumor progression and regulates the drug resistance of tumor cells.28 In HCC, miR-214-3p was suggested to suppress cell proliferation and cycle and showed a significant correlation with clinical prognosis.15 Moreover, miR-214-3p could mediate the induced effect of ketamine on ferroptosis of HCC and has been disclosed to mediate the function of lncRNA LINC00665, BACE-AS, HOXA11-AS, and several other lncRNAs in HCC development.16-20,29 Herein, miR-214-3p was negatively regulated by POLR2J4.