Long non-coding RNAs, in particular, have been recognized for their significant regulatory effect in human disease, influencing disease development and predicting patients’ outcomes.8,9 Recent studies identified potential biomarker lncRNAs in several human cancers, such as lncRNA HOTAIR in colorectal cancer, HOXA-AS3 in cervical cancer, and GAS8-AS1 in pancreatic cancer.10-12 In terms of HCC, several studies have established lncRNA signatures correlated with HCC development. The gene discussed is DRC4; the disease is hepatocellular carcinoma.