This poses a significant financial burden on society and families.1,21 Previously, abnormally expressed lncRNAs have been shown to signal the onset and development of malignant tumors, potentially improving therapeutic efficacy and patients’ outcomes.22 Although there is limited data on the specific function and importance of POLR2J4, several lncRNA signatures have highlighted its significance in predicting patients’ prognosis, especially in HCC. Here, POLR2J4 is linked to cancer.