Study has shown that NgR knockdown reduced amyloid plaque deposition and Aβ levels as well as improved spatial learning and memory in the APP/PS1 mouse model of Alzheimer's disease (AD) (Wang, Miao, et al., 2021, Wang, Qin, et al., 2021). The gene discussed is RTN4R; the disease is early-onset autosomal dominant Alzheimer disease.