GPX4 and Hepatic fibrosis: Excess iron deposition, generation of reactive oxygen species (ROS), aggregation of lipid peroxides, and the failure of glutathione peroxidase 4 (GPX4) activity are all key factors in inducing the onset of ferroptosis.4 Iron overload in the liver is a major causative factor in various types of liver injury diseases and is also associated with liver fibrosis.