In vitro, PC12 cells were treated with 6-OHDA, and CCK-8, specific kits, Hoechst 33258 staining, Western blotting, and JC-1 staining were performed to assess the IGFBP2's role.<h4>Results</h4>mRNA-seq revealed DEGs in PD, with attention to downregulated IGFBP2. This evidence concerns the gene IGFBP2 and Parkinson disease.