Along this line, a study comparing 100 European patients with MASLD‐related HCC to 275 patients with histological diagnosis of MASLD but without HCC highlighted a higher prevalence of the at‐risk PNPLA3 allele in the HCC group, also showing an adjusted 2‐time and 5‐time higher risk of HCC in patients with CG and GG genotype, respectively [75]. This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.