PNPLA3 and diabetes mellitus: Along this line, Moon and colleagues demonstrated that in a longitudinal study on a cohort of 8000 individuals who underwent at least 2 health check‐ups, the PNPLA3 rs738409 C > G variant was associated with a lower risk of developing diabetes in MASLD subjects [HR 0.65], while to a higher risk of occurrence of diabetes in individuals without MASLD [HR 2.4] [93].