PNPLA3 and obesity due to melanocortin 4 receptor deficiency: Along this line, data from the UK Biobank general population on more than 400 000 participants, as before showed for cirrhosis and liver‐related events, showed that PNPLA3 variant, obesity and alcohol use had a synergistic effect on the risk of liver‐related mortality, subjects with all the three risk factors having a 21 higher risk of liver‐related mortality respect to those without [65].