Along this line, a previous quoted Asiatic study on 477 patients with histological diagnosis of MASLD found that the PNPLA3 rs738409 GG genotype was significantly associated with a 3‐time higher risk of development of extrahepatic cancer, even if this association was lost after adjustment for severity of liver fibrosis [100]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.