In one prospective study of diabetic individuals, a PRS including PNPLA3, transmembrane 6 superfamily member 2 (TM6SF2) and SERPINA1 was associated with an increased risk of cirrhosis (p = 0.03) and, more interestingly, was associated with advanced fibrosis among those with FIB‐4 < 1.3 (p = 0.03) [57]. This evidence concerns the gene TM6SF2 and Cirrhosis.