PNPLA3 and hepatocellular carcinoma: A genome‐wide association study on case–control derivation and validation cohorts, analysed separately and then pooled by meta‐analysis identified five regions associated with HCC, including PNPLA3 rs738409; notably, the combination of homozygous variants of PNPLA3 and TERT revealed a 6.5‐fold higher risk for HCC respect to wild‐type subjects [77].