Along this line, in two large studies on patients with steatosis defined by increased ALT serum levels, from the Michigan Genomics Initiative—7893 individuals—and from the UK Biobank—46 880 individuals—PNPLA3‐rs738409‐GG genotype was associated with higher incidence rate of cirrhosis in both cohorts [63]. This evidence concerns the gene PNPLA3 and Cirrhosis.