PNPLA3 and Hepatic fibrosis: Despite a potential inverse association between diabetes development and PNPLA3 at risk genotypes, an analysis of 581 individuals with at least 3 metabolic risk factors found a direct and independent association between a procoagulant status assessed by factor VIII/ protein C ratio and both severity of liver fibrosis and the PNPLA3 rs738409 C > G variant [96].