PNPLA3 and metabolic dysfunction-associated steatotic liver disease: In this context, single nucleotide polymorphisms (SNPs) in the PNPLA3 (patatin‐like phospholipase domain‐containing protein 3) gene has been associated with a worse phenotype, promoting the progression of MASLD in the absence of strong metabolic dysfunction (e.g., the ‘lean MASLD’ phenotype) [8, 9, 10].