In a large UK Biobank cohort of more than 400 000 participants, 2398 of them developed cirrhosis, and the adjusted risk of cirrhosis was 17 times higher in individuals with excessive drinking, with obesity, and with PNPLA3 GG genotype, when compared to those without any of these 3 risk factors [65]. The gene discussed is PNPLA3; the disease is obesity due to melanocortin 4 receptor deficiency.