IL37 and cancer: TAMs can be remodeled by Proteostreptococcus,9 and chemotherapy resistance and tumor development are actively facilitated by the TME.24,25 The cytokine IL-23 is a crucial part of the TME and has drawn specific attention in studies of tumors.26 It is able to control the function of other cells in the TME, modulate the host immune response, and directly affect the behavior of both precancerous cells and malignant tumors.