Indeed, chemoresistant patients have been shown to exhibit increased Fusobacterium abundance, promoting the emergence of chemoresistance as a result of the regulation of autophagic activity.20 Fusobacterium-derived succinic acid can inhibit the cGAS-IFN-β pathway, thereby supporting CRC tumor resistance to immunotherapeutic interventions. This evidence concerns the gene IFNB1 and neoplasm.