Mechanistically, CRCSC-derived Exo-miR-17-5p was found to induce tumor progression and malignant behaviors by inhibiting speckle-type POZ protein (SPOP), and suppress anti-tumor immunity in CRC by blocking the expression of the programmed death ligand 1 (PD-L1).49 The gene discussed is SPOP; the disease is colorectal carcinoma.