The tumor-suppressive effect of BMSC-derived Exo-miRs on CRC was further supported by another in vitro study that revealed miR-16-5p-enriched BMSC-Exo inhibited proliferation, migration, and invasion, while promoting the CRC cell apoptosis by targeting and inhibiting the expression of ITGA2.41 In vivo studies indicated that the injection of miR-16-5p-enriched BMSC-Exo can reduce the ITGA2 expression in tumor tissues, thereby remarkably decreasing tumor progression and volume in CRC. Here, ITGA2 is linked to neoplasm.