SP1 and colorectal carcinoma: Of note, a study declared that Exo-miR-22-3p derived from human BMSCs (hBMSCs) can inhibit proliferation and invasion of CRC cells by modulating the activity of the RAP2B/PI3K/AKT pathway in the SW480 cell line.38 The tumor-suppressive impact of hBMSC-derived Exo-miR-22-3p has also been also reported by other studies that showed miR-22-3p-enriched hBMSC-Exo can suppress the development of non-small cell lung cancer (NSCLC).39 and hepatocellular carcinoma40 by downregulating the expression of astrocyte-elevated gene-1 (AEG-1) and specificity protein 1 (Sp1).