Contemporary research indicates that PGRN concentrations vary in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, potentially playing a role in their onset.[43] Furthermore, a connection to PGRN has been noted in allergic conditions such as asthma and atopic dermatitis.[19] Our research, emphasizing PGRN's influence on B‐cell activity and IgE synthesis, offers insights into possible focal points for the development of therapies for these medical conditions, which is particularly significant for the treatment of asthma. This evidence concerns the gene IGHE and systemic lupus erythematosus.