Recent studies have indicated that PGRN expression levels are altered in the bronchial tissues of asthmatic individuals, suggesting its association with disease development and severity.[18] Moreover, PGRN's interactions with various immune cells, including eosinophils and T cells, have been implicated in the modulation of airway inflammation and hyperresponsiveness in asthma.[19] As B cells play a central role in IgE production, investigating the interplay between PGRN and BCR signaling may provide critical insights into the mechanisms governing IgE‐mediated asthma. The gene discussed is BCR; the disease is asthma.