The initial stimulation of B cells via the B‐cell receptor (BCR) signaling pathway triggers the B‐cell‐driven humoral immune response, which is closely associated with IgE production.[3] Given the crucial role of IgE‐driven processes in both the onset and exacerbation of asthma, understanding the preliminary stages of BCR activation and their influence on IgE‐related asthma is essential. Here, IGHE is linked to asthma.