This study also identified the negative regulation of MAFF on KLF5 transcription in LN mouse and cell models through rescue experiments, which found the suppressive effect of HDAC6 inhibition on renal fibrosis and inflammation response can be abolished by KLF5 overexpression, suggested the involvement of the HDAC6/MAFF/KLF5 axis in LN. Here, KLF5 is linked to renal fibrosis.