Since β‐OHB abundance is decreased in the brain of AD patients and animal models, we focused on proteins with downregulated Kbhb modifications during disease progression (8‐month‐old APP/PS1 vs. 2‐month‐old APP/PS1) and disease onset (8‐month‐old APP/PS1 vs. 8‐month‐old WT). This evidence concerns the gene APP and Alzheimer disease.