Studies conducted in China suggest that rs6259 SNPis associated with the risk of MetS and accompanying lower serum SHBG levels in males of Chinese Han origin [49].However, gene polymorphisms of SHBG are also implicated in other conditions, including polycystic ovary syndrome, reduced bone mineraldensity and cancer of the breast and prostate. This evidence concerns the gene SHBG and polycystic ovary syndrome.