Recent experimental investigations have highlighted thekey finding that SHBG might be involved in regulating glucose metabolism through its influence on multiple GLUTs, thereby suggestingthat SHBG gene variations could have a crucial role in the development of IR and gestational diabetes [63].Further studies are required in the field of personalized medicine to fully elucidate the regulatory mechanisms of GLUTs modulated usingSHBG. This evidence concerns the gene SHBG and gestational diabetes.