Caglar et al.delineated the fact that a high predictive accuracy of SHBG in early pregnancy (13-16weeks) of GDM could warrant insulin therapy.Furthermore, subgroup analysis revealed that the predictive accuracy of SHBG remained consistent across different age groups and BMIcategories [42, 54 & 55].However, no significant difference in SHBG concentration was observed between individuals with normal glucose tolerance and those withabnormal glucose tolerance [56]. This evidence concerns the gene INS and gestational diabetes.