Histopathological changes in the kidney included glomerular hypertrophy, glomerulosclerosis, tubular dilation, protein cast formation and pronounced infiltration of mononuclear cells in the periglomerular and tubulo-interstitial area (glomerular lesion score: 2.67 +/- 0.52 AU; tubulo-interstitial lesion score: 2.83 +/- 0.41 AU), attributed in part by CD3+ and CD4+ T cells, CD19+ B cells and macrophages. Here, CD4 is linked to hypertrophy.