In 13 patients who had sera collected before active disease, CD44 level was increased in 10 patients (76.92%) at 4.50 ± 1.43 months prior to relapse and at the time of flare in the remaining 3 patients, whereas anti-dsDNA antibodies increased in 6 patients (46.15%) prior to clinical flare, in 1 patient at the time of flare and the remaining 6 patients showed normal anti-dsDNA antibody level during active LN. This evidence concerns the gene CD44 and lobular neoplasia.