Results from our histopathological studies showed that serum CD44 level was associated with activity index and correlated with the leukocyte infiltration and interstitial inflammation scores in renal biopsies from patients with active LN, whereas proteinuria and serum creatinine level was associated with one of these activity indices, and renal SLEDAI-2K score, anti-dsDNA antibody and C3 levels were not associated with parameters included in activity or chronicity indices. This evidence concerns the gene C3 and lobular neoplasia.