CD4 and lobular neoplasia: In healthy subjects, CD44 was expressed on resident macrophages, CD56dimCD16+NK cells, effector memory CD4+ T cells and resident memory CD8+ T cells, whereas CD44 was expressed in all immune cells identified in LN patients including tissue resident, inflammatory and phagocytic macrophages, naïve and activated B cells, Treg cells, effector and central memory CD4+ T cells and resident memory CD8+ T cells (Figures 2A–F).