There were no statistically differences between the two groups in terms of age, gender, largest tumor diameter, number of tumors, HBV infection status, Child-Pugh class, AFP levels, TBIL levels and ALB levels, presence of portal vein thrombosis (PVTT), prognostic nutritional index (PNI), extrahepatic metastasis and BCLC period (P>0.05). The gene discussed is AFP; the disease is Portal vein thrombosis.