The tissue-specific expression of NF-κB genes shows a notable prevalence in lymphocytes, with elevated expression levels of NFκB1, NFκB2, REL, and RELB potentially correlating to immune function dysregulation, characteristic of chronic inflammatory and neurodegenerative diseases—conditions possibly exacerbated by the stress of space flight (118–128). Here, NFKB1 is linked to neurodegenerative disease.