Studies conducted in vivo and in vitro have demonstrated that CAR-T cells target surface protein., including CD7, CD13, CD25, CD32, CD33, CD38, CD44, CD45RA, CD47, CD70, CD96, CD123, CLL-1, NKG2D ligand, Lewis Y antigen, Folate receptor β, FLT-3, CLEC12A, and TIM3, effectively eliminate AML cells (44) (Table 1). The gene discussed is CLEC12A; the disease is acute myeloid leukemia.