In Parkinson's disease (PD), which is marked by the loss of dopaminergic neurons and the formation of Lewy bodies, specific monogenic forms are linked to mutations in genes such as synuclein alpha (SNCA), leucine-rich repeat kinase 2 (LRRK2), parkin RBR E3 ubiquitin-protein ligase (PARK2), PTEN-induced putative kinase 1 (PINK1), and protein deglycase (DJ-1) [1]. Here, UBE2E3 is linked to Parkinson disease.