Although the details of the cancer destruction mechanism remain unclear, we speculate that radiotherapy might induce the reprogramming of TDLNs and TME from “cold” immunosuppressive to “hot” immunostimulatory state, which is preferable to activate DC1 to recognize common cancer antigens (WT-1, survivin) [13,15] presented by DC and neoantigens and other antigens released from cancer cells by irradiation-induced immunological cell death (ICD) [16]. Here, ZDHHC4 is linked to cancer.