In view of the strong association between CRP and IL-6, it is not surprising that IL-6 is also recognized as a major mediator of the acute phase response. Elevated IL-6 have also been indicated to forecast myocardial infarction and predict mortality in both pre-dialysis and HD patients [7,8] and can be a better predictor of cardiovascular mortality than CRP in these patients [9].Therefore, IL-6 measurement may have clinical utility as a predictive marker for atherosclerosis and its associated comorbidity. The gene discussed is CRP; the disease is myocardial infarction.