This aligns with the understanding that higher BMI, indicative of overweight and obesity, correlates with the heightened sympathetic drive, which is driven by higher levels of pro-inflammatory adipokines and fatty acids, impaired arterial baroreceptor function, insulin resistance, and increased circulating leptin and leptin receptor signaling in obesity [15]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.