Inherited forms of PD involve mutations in genes related to mitochondrial health, such as the E3-ubiquitin ligase Parkin, Leucine-rich repeat kinase 2 (LRRK2), PTEN-induced Kinase 1 (PINK1), and the protein deglycase DJ-1 (PARK7). The gene discussed is PRKN; the disease is Parkinson disease.