This condition is characterized by the presence of Th1 and Th17 cells, neutrophil infiltration, activation of NLRP3 inflammasome, and the release of cytokines such as INF-γ, IL-2, IL-1β, and IL-17.A mouse model of asthma treated with bacterial-derived histamine through the intragastric route reduced IL-4, IL-5, and IL-13 levels in the lungs. This evidence concerns the gene IL2 and asthma.