We have recently shown that exercise-induced lymphocytosis enhanced the efficacy of immunotherapy in people with chronic lymphocytic leukaemia (CLL) ex vivo via the mobilisation of effector (CD16+ NK-cells) and target (CLL) cells – including B-cells with a phenotype indicative of lymphoid origin – into blood (Collier-Bain et al., 2024a). This evidence concerns the gene FCGR3B and B-cell chronic lymphocytic leukemia.