Table 1 showed that two highly recurrent TTN-LSM1 and TTN-LMF1 HFGs of twenty-one 3′-TTN-fused HFGs were detected in 40.2% and 23.8% of 122 DCM patients and were 5.3- and 8.6-fold of the GTEx counterparts. Figure 2C showed that TTN and LSM1 were located on 2q31.2 and 8q11.2 and encoded titin and LSM1 homolog. A potential translocation produced a TTN-LSM1 fusion structure to generate TTN-LSM1 HFG encoding 3664 aa titin- LSM1 homolog fusion protein, which was only 11% of 33,430 titin (NM_133378.4). This evidence concerns the gene LSM1 and familial dilated cardiomyopathy.