Our Spearman correlation analysis reveals significant correlations between HDAC6 and key pathways, including DNA replication, tumor proliferation signature, G2M checkpoint, p53 pathways, and PI3K/AKT/mTOR signaling pathways, as well as between DNMT3B and DNA replication, tumor proliferation signature, and G2M checkpoint signaling pathways, revealing the potential role of the HDAC6 gene in HPV infection-related cervical cancer. This evidence concerns the gene TP53 and cervical cancer.