E2F1 and cancer: Furthermore, the DisGeNET pathway analysis indicated these genes were mainly enriched in Mitotic G1 G1/S phases, Diseases of signal transduction, S phase, G1/S Transition, Interleukin-4 and 13 signaling, PI3K/AKT Signaling in Cancer, TP53 Regulates Transcription of Cell Cycle Genes, G1 phase, Activation of E2F1 target genes at G1/S, and Transcription of E2F targets under negative control by DREAM complex (Figure 3C).