Several of these DEPs are involved in various canonical pathways, as well as in cellular and molecular functions germane to cardiometabolic disease, including insulin secretion signaling pathway, NAFLD pathway, PPARAα/RXRα activation, NF-kB signaling, mTOR signaling, TR/RXR activation, and VEGF signaling, diabetes mellitus, insulin resistance, metabolic syndrome, concentration of cholesterol, steatohepatitis, glucose metabolism disorder, and hepatic steatosis. This evidence concerns the gene INS and fatty liver disease.