STAT3 and cardiovascular disorder: Meanwhile, we pinpointed numerous canonical pathways (CP) that were enriched in the DEPs proteins and that were relevant to metabolic and cardiovascular disorders, including Neutrophil degranulation, IL-15 Production, IL-8 Signaling, FXR/RXR Activation, IL-17 Signaling, Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes,IL-33 Signaling Pathway,IL-13 Signaling Pathway,STAT3 Pathway,WNT/β-catenin Signaling,IL-3 Signaling (Figures 5A, B).