Several of these DEPs are involved in various canonical pathways, as well as in cellular and molecular functions germane to cardiometabolic disease, including insulin secretion signaling pathway, NAFLD pathway, PPARAα/RXRα activation, NF-kB signaling, mTOR signaling, TR/RXR activation, and VEGF signaling, diabetes mellitus, insulin resistance, metabolic syndrome, concentration of cholesterol, steatohepatitis, glucose metabolism disorder, and hepatic steatosis. Here, INS is linked to diabetes mellitus.