NQO1 and Parkinson disease: Studies of single-neuron neurodegeneration as a degenerative model for PD propose that an endogenous neurotoxin, aminochrome, affects a single neuron and triggers the neurodegenerative process, which can be protected by DT-diaphorase (NQO1) and glutathione transferase M2-2, the downstream enzymes of NRF2 (Huenchuguala and Segura-Aguilar, 2024a,b).