Prior work has also shown that RBD has reduced striatal DAT binding compared with controls and higher striatal DAT binding compared with Parkinson’s disease without an RBD diagnosis.34,78,79 There is also evidence of reduced striatal DAT binding longitudinally over 3 years in RBD compared with controls.36 Additionally, a prior study using 11C-MeNER and 18F-DOPA PET imaging found that individuals with RBD have a reduction of sensorimotor cortex 11C-MeNER binding compared with controls. This evidence concerns the gene SLC6A3 and Parkinson disease.