SREBF1 and lung carcinoma: According to previous reports, nuclear PKM2 promotes the proliferation of liver, breast, colon, and lung cancer cells by phosphorylating nuclear sterol regulatory element-binding protein (SREBP)-1a T59, which prevents SREBP-1a from being ubiquitinated and degraded and consequently enhances the expression of SREBP-1a’s target genes related to lipid metabolism.