TP53 and endometrial cancer: On the basis of the outcomes of the Cancer Genome Atlas, and the ProMisE (Proactive Molecular Risk Classifier for EC), endometrial cancer is divided into four subgroups: POLEmut, p53 wild type (low copy number—CNL—or nonspecific molecular profile—NSMP), p53 null/missense mutations (high copy number), and mismatch repair deficient (MMRd) (13).