Response rate- CR was defined as the complete disappearance of all objective evidence of disease including the decrease of HCG and/or AFP to the normal limits for at least 1-month duration.- The decrease of HCG and/or AFP to the normal limit but with persistence of tumor masses on the CT was classified as PRm−.- Patients who achieved other results than CR or PRm− were classified as treatment failures.Overall survival at 1 year and 2 years.Toxicity grade 3–5d. This evidence concerns the gene AFP and neoplasm.