These findings were supported by a study on MM patients to understand their reliance on Bcl-2, Bcl-xL, and Mcl-1 using BH3 mimetics, which also showed that Bcl-2 dependency was high in a specific subgroup, while Mcl-1 dependency increased significantly from diagnosis to relapse, suggesting a shift towards Mcl-1 dependency at relapse (Gomez-Bougie et al., 2018). This evidence concerns the gene BCL2L1 and Miyoshi myopathy.