We generated resistant cells to a variety of MM chemotherapeutic drugs (bortezomib, lenalidomide, venetoclax, and ABT-737) and discovered that all resistant cell lines express a different pattern of anti-apoptotic Bcl-2 family proteins, notably high level of Mcl-1 (Supplementary Figures S5A, B). Here, MCL1 is linked to Miyoshi myopathy.