found that NMN supplementation can alleviate vascular oxidative stress and improve arteriosclerosis and functional impairment; moreover, NMN reduces vascular collagen, increases arterial elastin, reduces arteriosclerosis, and delays arterial aging; this demonstrates the potential role of NMN in protecting vascular health (Picciotto et al., 2016; Tarantini et al., 2019). This evidence concerns the gene ELN and arteriosclerosis.