Most DEE cases (30–50%) have a sporadic de novo cause with over 50 genes associated with DEE (Bertocchi et al., 2023), including genes that encode for various ion channels including potassium channels (KCNA, KCNB and KCNQ subfamilies) (Wang et al., 2022). The gene discussed is KCNA3; the disease is developmental and epileptic encephalopathy.