These results support the hypothesis of a previous study that suggested that the genotype of Hp has a crucial role in modulating the oxidative-antioxidative status in both obesity and diabetes (43) and reveal the positive impact/response of RIF based on the inflammatory status, which significantly elevated in the higher proinflammatory genotype Hp2-2 in order to modulate the inflammatory response. The gene discussed is HP; the disease is obesity due to melanocortin 4 receptor deficiency.