A recent meta-analysis comprising 30 studies from clinical trials and cohorts (n = 44,889) aimed to assess the predictive utility of serum NT-proBNP levels in T2DM complications and reported a moderate level of evidence for predicting cardiovascular and all-cause mortalities at NT-proBNP levels of >100 and >225 pg/mL, respectively [36]. This evidence concerns the gene NPPB and type 2 diabetes mellitus.