SHBG and preeclampsia: We also did not find a significant difference in SHBG levels of the groups that later did or did not develop preeclampsia, which is in line with the findings of other groups demonstrating no predictive value of prepregnancy SHBG levels for preeclampsia in the merged data from two large prospective cohort studies, mentioned above [37], or in the study by Spencer et al., analyzing the correlation of first trimester SHBG levels with subsequent preeclampsia [50].