HSPD1 and osteoarthritis: The statistically significant very strong negative correlation between HSP60-positive chondrocytes and Col-I-positive chondrocytes could indicate that HSP60 might negatively affect normal chondrocyte metabolism and extracellular matrix production, although the opposite has been documented in previous research in that HSP60 activity in inflamed hyaline cartilage damaged by osteoarthritis helps to prevent the loss of cartilage matrix [20].