Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by clinical manifestations such as arterial thrombosis (AT), venous thrombosis (VT) and pregnancy morbidity, in which antiphospholipid antibodies (aPL) are positive at least 12 weeks apart [1]. The gene discussed is FASLG; the disease is autoimmune polyendocrinopathy.