In addition, the finding that men are more sensitive to kidney damage than women, there is increased expression of androgen receptors in the glomeruli, there is increased glomerular RAAS activation in the presence of androgens, there is a higher frequency of kidney dysfunction in androgenic PCOS models, and high GFR rates are reported in many PCOS patients all support the long-term adverse effects of androgens in podocyte injury [13,29,30,31,32]. This evidence concerns the gene AR and polycystic ovary syndrome.