The NGS analysis identified a deleterious mutation in the CTNNB1 gene variation c.114_149del p.(Ala39_Gly50del) (Frequency 16.4% of 1846 NGS reads) in a 24-year-old female patient with abdominal wall desmoid-type fibromatosis. The gene discussed is CTNNB1; the disease is desmoid tumor.