AKT1 and fibromatosis: Meazza et al. investigated 16 sporadic cases of pediatric aggressive fibromatosis using NGS and discovered that, in addition to the CTNNB1 gene mutation, five cases (31%) had AKT1 E17K (25%), BRAF V600E (12%), TP53 R273H (6%), and RET V648I (6%) mutations [73].