For example, the overexpression of TFF1 suppressed nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-kB) signaling and, therefore, pro-tumorigenic and metastatic properties in colon and gastric cancer cells [49,50] as well as ß-catenin signaling in hepatocellular carcinoma cells [51]. Here, TFF1 is linked to hepatocellular carcinoma.