NDUFS1 and Brain atrophy: Neuroimaging revealed cavitations in the basal ganglia area with brain atrophy, a mandatory differential diagnosis with CI deficiency by NADH:ubiquinone oxidoreductase core subunit S1 (NDUFS1) and NADH:ubiquinone oxidoreductase core subunit V1 (NDUFV1) mutations [34], as biotin responsive basal ganglia disorders (BBGDs) are treatable.