Notably, adiponectin, a crucial adipokine produced by fat cells, can activate various signaling pathways including mitogen-activated protein kinase (MAPK), adenosine monophosphate-activated protein kinase (AMPK), and phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) leading to the suppression of tumor formation induction [26,27]. Here, PIK3CA is linked to neoplasm.