Genes like nucleotide-binding oligomerization domain-containing protein 2 (NOD2), recombination activating gene 2 (RAG2), interleukin 10 (IL-10) receptor deficiency, the autophagy gene (ATG16L1), and nuclear factor kappa beta (NF-kB) essential modulator (NEMO) have all been associated with IBD [16]. This evidence concerns the gene NOD2 and inflammatory bowel disease.