We previously found that administration of a non-polyphenol extract of cranberry fruit containing primarily triterpenoids and sterols (0.05% w/w in diet) to AOM-DSS treated mice was able to reduce tumor burden by 40%, with a significant reduction in the expression of pro-inflammatory markers IL-6, IL-1β, and TNF-α in colonic tissue [11]. This evidence concerns the gene IL6 and infectious otitis media.