Signaling via the Hippo pathway, including its effectors YAP/TAZ, drives the expression/secretion of numerous cytokines (e.g., IL-4, IL-6, CSF-1) that help recruit monocytes to the TME, followed by their M2-like polarization into TAMs that express tumor immune checkpoints such as PD-1 [33]. Here, IL4 is linked to neoplasm.