Repression of tumor immunity, within the TME, can also occur via tumor cell secretion of paracrine-acting factors (e.g., IL-10 and PGE2), resulting in polarization of monocytic MDSCs into M2-like TAMs; analogously, inhibition of prostaglandin synthesis (via COX2 inhibition) reversed this effect [12,13]. This evidence concerns the gene IL10 and neoplasm.