For example, the occurrence of an SFPQ::TFE3 translocation in a PAX8-positive renal tubular stem cell will give rise to renal cell carcinoma, which has a 78%, 38%, and 44% chance of staining for CD10, cathepsin K, and HMB45, respectively. The gene discussed is PAX8; the disease is hereditary clear cell renal cell carcinoma.