All carcinomas with ASPL/ASPSCR1::TFE3 fusion were classified into the high angiogenesis/stroma/proliferation cluster, whereas half of the MED15::TFE3 and SFPQ/PSF::TFE3 tumors were included in the cluster enriched for EMT, apical junction, TGF-β, WNT catenin, and hypoxia signaling. The gene discussed is TFE3; the disease is carcinoma.