As far as the genetic alternations are concerned, in some tumors, the TFE3 gene constantly shows specific translocations: among these, the ASPL/ASPSCR1::TFE3 rearrangement in alveolar soft part sarcoma [12], the YAP1::TFE3 fusion in clear cell stromal tumor of the lung [13] and a subset of epithelioid angiomyolipoma [14], and the PHF1::TFE3 translocation in ossifying fibromyxoid tumor [15]. This evidence concerns the gene ASPSCR1 and ossifying fibromyxoid tumor.