Identical translocations involving the TFE3 gene and various partner genes have been found in both renal and soft tissue tumors, such as alveolar soft part sarcoma (ASPSCR1 gene), ossifying fibromyxoid tumor (PHF1 gene), epithelioid hemangioendothelioma, and clear cell stromal tumor of the lung (YAP1 gene). This evidence concerns the gene PHF1 and soft tissue neoplasm.