However, the first description of TFE3-rearranged renal cell carcinoma is commonly considered in 2001 by Argani who reported eight renal tumors arising in children characterized by a t(X;17)(p11.2;q25) translocation, which fuses the ASPL/ASPSCR1 and TFE3 genes [29]. The gene discussed is TFE3; the disease is hereditary clear cell renal cell carcinoma.