Identical translocations involving the TFE3 gene and various partner genes have been found in both renal and soft tissue tumors, such as alveolar soft part sarcoma (ASPSCR1 gene), ossifying fibromyxoid tumor (PHF1 gene), epithelioid hemangioendothelioma, and clear cell stromal tumor of the lung (YAP1 gene). The gene discussed is PHF1; the disease is alveolar soft part sarcoma.