LGR5 and neoplasm: Irradiated male Lgr5+Apc1638N/+ mice showed the highest tumor incidence in 28Si (7.83 ± 1.10, n = 9) relative to γ-ray (4.73 ± 0.27, n = 15) or control (2.88 ± 0.17, n = 15) group (Figure S1C).