It is important to note here that the Renca cell line we used for our studies has wild type VHL expression and, therefore, relatively low endogenous levels of HIF1α; forced VHL knockdown in the Renca cell line causes high expression of HIF1α and accelerated tumor growth marked by phenotypic and morphologic changes consistent with epithelial-to-mesenchymal transition and increased metastases [47]. The gene discussed is VHL; the disease is neoplasm.