Lung metastases were not examined by Ferrere et al. Instead, the authors focused on deciphering the mechanisms by which KD or administered βHB slowed tumor outgrowth in a subcutaneous melanoma model, finding that oral βHB + ICB yielded the best survival results in a manner that appeared to depend upon beneficial gut microbiota changes and CXCR3 expression on CD8+ T cells [18]. This evidence concerns the gene CD8A and melanoma.