In another glioblastoma-focused paper, Lussier et al. found that administration of a KD increased CD4+ T cell infiltration within intracranial tumors and reduced the percentages of CD8+ T cells expressing PD-1 or CTLA-4, observations that were associated with increased CD8+ T cell cytolytic activity [39]. This evidence concerns the gene CTLA4 and glioblastoma.