CD8A and neoplasm: Notably, dietary administration of the same ketone ester used in our eKET diet formulation (BD-AcAc2) was also effective at delaying tumor outgrowth alone and in the context of ICB, through both tumor intrinsic mechanisms that included HDAC inhibition and extrinsic mechanisms that relied upon CXCL10/CXCR3-mediated recruitment of CD8+ T cells into tumors [6].